Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

October 16, 2019

Primary Completion Date

September 21, 2023

Study Completion Date

January 8, 2024

Conditions
Pancreatic CancerMetastatic Castration-resistant Prostate CancerBladder CancerMelanomaNon-small Cell Lung CancerColorectal CancerGastric CancerEsophageal CancerOvarian CancerHead Neck Squamous Cell CarcinomaProstate Cancer
Interventions
BIOLOGICAL

NGM120 30mg

NGM120 30mg Subcutaneous Injection

BIOLOGICAL

NGM120 100mg

NGM120 100mg Subcutaneous Injection

BIOLOGICAL

NGM120 30mg with Gemcitabine and Abraxane

NGM120 30mg Subcutaneous Injection together with gemcitabine (1000 mg/m2 weekly for first 3 weeks of the 4-week cycle) and Abraxane (125 mg/m2 weekly for first 3 weeks of the 4-week cycle).

BIOLOGICAL

NGM120 100mg with Gemcitabine and Abraxane

NGM120 100 mg Subcutaneous Injection together with gemcitabine (1000 mg/m2 weekly for first 3 weeks of the 4-week cycle) and Abraxane (125 mg/m2 weekly for first 3 weeks of the 4-week cycle).

BIOLOGICAL

NGM120 100mg Q3W

NGM120 100mg Subcutaneous Injection every 3 weeks

OTHER

Placebo

Placebo

Trial Locations (20)

19111

NGM Clinical Study Site, Philadelphia

20007

NGM Clinical Study Site, Washington D.C.

21201

NGM Clinical Study Site, Baltimore

29425

NGM Clinical Study Site, Charleston

29572

NGM Clinical Study Site, Myrtle Beach

33136

NGM Clinical Study Site, Miami

37203

NGM Clinical Study Site, Nashville

45219

NGM Clinical Study Site, Cincinnati

53226

NGM Clinical Study Site, Milwaukee

60611

NGM Clinical Study Site, Chicago

75390

NGM Clinical Study Site, Dallas

77030

NGM Clinical Study Site, Houston

80045

NGM Clinical Study Site, Aurora

85719

NGM Clinical Study Site, Tucson

90048

NGM Clinical Study Site, Los Angeles

90084

NGM Clinical Study Site, Los Angeles

90404

NGM Clinical Study Site, Santa Monica

92123

NGM Clinical Study Site, San Diego

98101

NGM Clinical Study Site, Seattle

98517

NGM Clinical Study Site, Sacramento

Sponsors
All Listed Sponsors
lead

NGM Biopharmaceuticals, Inc

INDUSTRY