RANKL Inhibition and Mammographic Breast Density

Denosumab is commercially available and will be provided at no cost to participants.

Placebo will be made available as 1 mL sterile, non-pyrogenic water solution in a single-use prefilled syringe.

-Participants will be instructed to take calcium (at least 500 mg) daily for 12 months between baseline examination and 12- month mammographic breast density examination.

Participants will be instructed to take vitamin D3 (at least 400 IU) supplements daily for 12 months between baseline examination and 12- month mammographic breast density examination.

Baseline and 12 months

Baseline and 12 months