NCT04062721View on ClinicalTrials.gov

Local Immunomodulation After Radiofrequency of Unresectable Colorectal Liver Metastases

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

November 30, 2028

Study Completion Date

November 30, 2028

Conditions
Unresectable Colorectal Liver Metastases
Interventions
DRUG

Chemotherapy

Chemotherapy (at the investigator's choice) for ≥ 2 months before RFA (with controlled disease) and resumed 4-6 weeks after RFA to achieve 6-month total duration.

PROCEDURE

Radiofrequency ablation (RFA)

Complete macroscopic ablation by RFA.

DRUG

In situ immunotherapy

Hydrogel combining TLR or NOD2 agonist and GM-CSF will be injected in 1, 2 or 3 distinct lesions after RFA.

Trial Locations (1)

92100

Digestive Surgery Department, Ambroise Pare University Hospital, APHP, Boulogne-Billancourt

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER