Transcranial Magnetic Stimulation (TMS) in Multiple Sclerosis

PHASE1/PHASE2UnknownINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

October 1, 2019

Primary Completion Date

October 1, 2021

Study Completion Date

October 1, 2022

Conditions
Multiple Sclerosis
Interventions
DEVICE

Transcranial Magnetic Stimulation (TMS)

"By means of the magnetic stimulator we induce a cerebral electric current that is able to obtain a motor potential in the first dorsal interosseous bone of the left hand.~The intervention procedure consists of two steps: First step: Obtaining the Motor Evoked Threshold at Rest: Each patient, regardless of to the group to which they belong will have his/her threshold evoked motor calculated at rest, by stimulation of the right motor cortex, evoking electromyographic responses in the contralateral muscles. Second step: Administration of TMS: To calculate the motive threshold as the percentage of the same to which the treatment will have to be applied, a device equipped with a coil. The treatment will be administered for 5 consecutive days, with 3 weeks of rest, between each stimulation. To complete a treatment period of 14 months. The stimulation with TMS will be carried out every day in the same time slot for 5 consecutive days every 4 weeks, during a period of 14 months."

DRUG

Placebos

Administration of Transcranial Magnetic Stimulation at 0 Hz (the patient will be only under drug standar therapy)

All Listed Sponsors
collaborator

Isaac Tunez-Fiñana

UNKNOWN

collaborator

Eduardo Agüera-Morales

UNKNOWN

lead

Maimónides Biomedical Research Institute of Córdoba

OTHER