Preventing de Novo Portal Vein Thrombosis With Antithrombin-III in Patients With Cirrhosis

PHASE1WithdrawnINTERVENTIONAL
0
Timeline

Start Date

January 1, 2021

Primary Completion Date

February 22, 2022

Study Completion Date

February 22, 2022

Conditions
Portal Vein ThrombosisCirrhosis, Liver
Interventions
DRUG

Antithrombin III

"Patients with reversal of flow or sluggish flow in the main portal vein (\<15 cm/s by Doppler ultrasound exam) will be enrolled and randomized to either weekly infusions of AT-III (half-life \~4 days) at a weight-based dosage according to the following formula:~\[Desired level of AT (100%) - Subject level of AT (%)\] \* subject weight (kg) 1.4~or placebo for 24 weeks of therapy."

OTHER

Placebo

No study drug

Trial Locations (1)

17033

Penn State College of Medicine, Hershey

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Grifols Therapeutics LLC

INDUSTRY

lead

Jonathan Stine

OTHER

NCT04055389 - Preventing de Novo Portal Vein Thrombosis With Antithrombin-III in Patients With Cirrhosis | Biotech Hunter | Biotech Hunter