Reduction of Postoperative Wound Infections by Antiseptica?

PHASE3CompletedINTERVENTIONAL
Enrollment

456

Participants

Timeline

Start Date

February 1, 2015

Primary Completion Date

September 10, 2018

Study Completion Date

October 20, 2018

Conditions
Surgical Site Infection
Interventions
DRUG

Polihexanide; Serasept

"Experimental arm: irrigation of subcutaneous tissue after fascia closure with polihexanide (ten minutes).~A single dose of perioperative antibiotics (cefuroxim alone or cefuroxim and metrodidazole in bowel surgeries) was given 30 minutes before skin incision.~Hair removal was done with electronic clippers and preoperative skin antisepsis was performed with propanol and povidone-iodine.~Before closure of fascia, instruments and gloves were changed. No subcutaneous suture was used. Skin was closed either with skin staples, continuous intracutaneous suture or interrupted suture.~All surgeries were done according to the Standard Operating Procedures of the Department for General, Visceral and Vascular Surgery, Charité Campus Benjamin Franklin."

DRUG

NaCl; saline

"Control arm: irrigation of subcutaneous tissue after fascia closure with NaCl (one minute) A single dose of perioperative antibiotics (cefuroxim alone or cefuroxim and metrodidazole in bowel surgeries) was given 30 minutes before skin incision.~Hair removal was done with electronic clippers and preoperative skin antisepsis was performed with propanol and povidone-iodine.~All surgeries were done according to the Standard Operating Procedures of the Department for General, Visceral and Vascular Surgery, Charité Campus Benjamin Franklin.~Before closure of fascia, instruments and gloves were changed. No subcutaneous suture was used. Skin was closed either with skin staples, continuous intracutaneous suture or interrupted suture.~All surgeries were done according to the Standard Operating Procedures of the Department for General, Visceral and Vascular Surgery, Charité Campus Benjamin Franklin."

Trial Locations (1)

12200

Charité Campus Benjamin Franklin, Steglitz

All Listed Sponsors
lead

Johannes Lauscher

OTHER

NCT04055233 - Reduction of Postoperative Wound Infections by Antiseptica? | Biotech Hunter | Biotech Hunter