GLAD-AML - Glasdegib (Pf-04449913) With Two Standard Decitabine Regimens for Older Patients With Poor-risk Acute Myeloid Leukemia

PHASE2TerminatedINTERVENTIONAL
Enrollment

1

Participants

Timeline

Start Date

December 6, 2019

Primary Completion Date

June 9, 2020

Study Completion Date

June 9, 2020

Conditions
ACUTE MYELOID LEUKEMIA
Interventions
DRUG

Glasdegib

Glasdegib will be administered at the starting dose of 100 mg orally once daily.

DRUG

Decitabine

Decitabine will be administered per local label and will be administered by IV infusion at a dose of 20 mg/m2/day for either 5 days or 10 days as determined by randomization. Each cycle will be every 28 days.

Trial Locations (1)

06511

Yale Cancer Center/Smilow, New Haven

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Yale University

OTHER

NCT04051996 - GLAD-AML - Glasdegib (Pf-04449913) With Two Standard Decitabine Regimens for Older Patients With Poor-risk Acute Myeloid Leukemia | Biotech Hunter | Biotech Hunter