41
Participants
Start Date
July 22, 2019
Primary Completion Date
March 28, 2023
Study Completion Date
March 28, 2023
Tiragolumab
Administered by IV infusion at a fixed dose of 600 mg on Day 1 of each 21-day cycle (Q3W)
Daratumumab/rHuPH20
Administered by SC injection 1800 mg/30,000 U rHuPH20 weekly for a total of 6 doses, then every 3 weeks for a total of 16 doses (first dose given at Week 7), then every 4 weeks from Week 55 onward until disease progression
Rituximab
Administered for a total of 8 doses. Rituximab will be administered by IV infusion for the first dose at a dose of 375 mg/m\^2. After administration of at least one full infusion of IV rituximab, the SC formulation of rituximab (rituximab and rHuPH20) may be used for the remaining doses per institutional guidelines. SC rituximab will be administered at a dose of 1400 mg rituximab/23400 U rHuPH20 once weekly (QW).
Atezolizumab
Administered by IV infusion at a fixed dose of 1200 mg Q3W
Clinical Research Alliance, Westbury
University of Pennsylvania; School of Medicine, Philadelphia
University of Maryland, Baltimore
Virginia Cancer Specialists (Fairfax) - USOR, Fairfax
Emory Clinic, Atlanta
SCRI, Nashville
Oncology Hematology Care, Inc., Cincinnati
Washington University, St Louis
Colorado Blood Cancer Institute (CBCI) at Presbyterian/ St. Luke's Medical Center, Denver
Samsung Medical Center; Nephrology Department, Seoul
Seoul National University Hospital, Seoul
Yonsei Cancer Center; Yonsei Uni Coll. Med., Seoul
Seoul St.Mary's Hospital; Medical Oncology, Seoul
Asan Medical Center; Internal Dept / Gastorenterology, Seoul
Lead Sponsor
Genentech, Inc.
INDUSTRY