A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Activity of Tiragolumab in Participants With Relapsed or Refractory Multiple Myeloma or With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

PHASE1TerminatedINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

July 22, 2019

Primary Completion Date

March 28, 2023

Study Completion Date

March 28, 2023

Conditions
Multiple MyelomaNon-Hodgkin LymphomaB-Cell Lymphoma
Interventions
DRUG

Tiragolumab

Administered by IV infusion at a fixed dose of 600 mg on Day 1 of each 21-day cycle (Q3W)

DRUG

Daratumumab/rHuPH20

Administered by SC injection 1800 mg/30,000 U rHuPH20 weekly for a total of 6 doses, then every 3 weeks for a total of 16 doses (first dose given at Week 7), then every 4 weeks from Week 55 onward until disease progression

DRUG

Rituximab

Administered for a total of 8 doses. Rituximab will be administered by IV infusion for the first dose at a dose of 375 mg/m\^2. After administration of at least one full infusion of IV rituximab, the SC formulation of rituximab (rituximab and rHuPH20) may be used for the remaining doses per institutional guidelines. SC rituximab will be administered at a dose of 1400 mg rituximab/23400 U rHuPH20 once weekly (QW).

DRUG

Atezolizumab

Administered by IV infusion at a fixed dose of 1200 mg Q3W

Trial Locations (14)

11590

Clinical Research Alliance, Westbury

19104

University of Pennsylvania; School of Medicine, Philadelphia

21201

University of Maryland, Baltimore

22031

Virginia Cancer Specialists (Fairfax) - USOR, Fairfax

30322

Emory Clinic, Atlanta

37203

SCRI, Nashville

45236

Oncology Hematology Care, Inc., Cincinnati

63128

Washington University, St Louis

80218

Colorado Blood Cancer Institute (CBCI) at Presbyterian/ St. Luke's Medical Center, Denver

06351

Samsung Medical Center; Nephrology Department, Seoul

110-744

Seoul National University Hospital, Seoul

120-752

Yonsei Cancer Center; Yonsei Uni Coll. Med., Seoul

137-807

Seoul St.Mary's Hospital; Medical Oncology, Seoul

138-736

Asan Medical Center; Internal Dept / Gastorenterology, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY