57
Participants
Start Date
September 24, 2019
Primary Completion Date
August 31, 2024
Study Completion Date
August 31, 2024
GnRH antagonist
GnRH antagonist will be given once for premenopausal women (12-week intervention) and twice for postmenopausal women (24-week intervention)
Estrogen Product
Estrogen patches will be worn by those randomized to the Estradiol arms in both premenopausal and postmenopausal groups. Patches will be applied weekly and will be worn for the for entirety of the intervention (12 or 24 weeks).
Placebo estradiol
Placebo patches will be worn by those randomized to the placebo arms in both premenopausal and postmenopausal groups. Patches will be applied weekly and will be worn for the for entirety of the intervention (12 or 24 weeks).
Placebo GnRH antagonist
Postmenopausal women randomized to the placebo injection arm will receive two placebo drug injections of normal saline (24-week intervention)
RECRUITING
University of Colorado - Anschutz Medical Campus, Aurora
National Institute on Aging (NIA)
NIH
University of Colorado, Denver
OTHER