A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor

PHASE1/PHASE2SuspendedINTERVENTIONAL
Enrollment

227

Participants

Timeline

Start Date

July 29, 2019

Primary Completion Date

July 31, 2023

Study Completion Date

January 31, 2024

Conditions
Advanced Solid TumorGynecologic Cancer
Interventions
DRUG

Lucitanib

Oral lucitanib will be administered once daily (QD) at the starting dose of 6 mg.

DRUG

Lucitanib

Oral lucitanib will be administered once daily (QD). The dose will be 6 mg.

DRUG

Lucitanib

"Oral lucitanib will be administered once daily (QD) at the starting dose of 6 mg.~Subjects will be allowed to intrapatient dose escalate in increments of 2 mg up to a total dose of 10 mg QD lucitanib if they meet the study specific clinical criteria."

DRUG

Nivolumab

IV nivolumab 480 mg will be administered once every 4 weeks.

Trial Locations (27)

1200

Saint Luc Univerisity Hospital, Brussels

3000

University Hospitals Leuven, Campus Gasthuisberg, Leuven

6020

Medical University of Innsbruck, Innsbruck

9000

University Hospital Ghent, Ghent

10016

NYU Langone Laura and Isaac Perlmutter Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

14004

University Hospital Reina Sofia, Córdoba

15213

Magee-Womens Hospital of UPMC, Pittsburgh

27710

Duke University School of Medicine, Durham

28027

Navarra University Clinic, Madrid

28046

La Paz University Hospital, Madrid

34232

Florida Cancer Specialists, Sarasota

37203

Tennessee Oncology, Nashville

40138

Polyclinic S. Orsola-Malpighi, Bologna

43210

Ohio State University Wexner Medical Center, Columbus

45136

Kliniken Essen-Mitte, Essen

68167

University Hospital Mannhein, Mannheim

73104

Stephenson Cancer Center, Oklahoma City

80045

Anschutz Cancer Pavilion, Aurora

80131

"National Cancer Institute -IRCCS Fondazione G. Pascale", Naples

90095

UCLA Jonsson Comprehensive Cancer Center, Los Angeles

92093

UC San Diego Moores Cancer Center, San Diego

98107

Swedish Cancer Institute, Seattle

02114

Massachusetts General Hospital, Boston

01307

University Hospital Carl Gustav Carus, Dresden

00168

Foundation IRCCS Hospital Agostino Gemelli, Rome

08035

University Hospital Vall d'Hebron, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

lead

Clovis Oncology, Inc.

INDUSTRY