Evaluating the Safety and Immunogenicity of a Prime-boost Vaccine Regimen of GEO-D02 DNA and MVA/HIV62B With and Without B63521^11 gp120 and IHV01 gp120 Env Proteins in Healthy, HIV-uninfected Adult Participants

PHASE1WithdrawnINTERVENTIONAL
0
Timeline

Start Date

March 1, 2022

Primary Completion Date

September 30, 2022

Study Completion Date

May 31, 2023

Conditions
HIV Infections
Interventions
BIOLOGICAL

GEO-D02 DNA

Administered by IM injection into the vastus lateralis

BIOLOGICAL

MVA/HIV62B Vaccine

Administered by IM injection into the vastus lateralis

BIOLOGICAL

B63521^11 gp120

Administered as a IM or SC injection into the vastus lateralis or overlying subcutaneous tissue as the MVA dose

BIOLOGICAL

IHV01 Protein

Administered as a IM or SC injection into the vastus lateralis or overlying subcutaneous tissue as the MVA dose

BIOLOGICAL

Protein Placebo

"Sodium Chloride for Injection, 0.9% USP~Administered as a IM or SC injection into the vastus lateralis or overlying subcutaneous tissue as the MVA dose"

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

HIV Vaccine Trials Network (HVTN), Fred Hutch / University of Washington

UNKNOWN

collaborator

GeoVax Labs, Inc

UNKNOWN

collaborator

Duke University

OTHER

collaborator

University of Maryland, Baltimore

OTHER

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH