Study to Evaluate Sacituzumab Govitecan in Combination With Talazoparib in Patients With Metastatic Breast Cancer.

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

October 9, 2019

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Breast Cancer
Interventions
DRUG

Talazoparib

Talazoparib belongs to a group of drugs called PARP inhibitors. PARP is a protein that is involved with repairing damaged DNA (the genetic material of cells). Talazoparib is believed to work by inhibiting (stopping) the PARP proteins from working in the cancer cells so that the cancer cannot fix its damaged DNA.

DRUG

Sacituzumab Govitecan

Sacituzumab govitecan is believed to work by binding the antibody portion of the drug to the tumor(s) while the anticancer drug portion works to prevent the cancer cells from growing/spreading.

Trial Locations (2)

02115

RECRUITING

Massachusetts General Hospital Cancer Center, Boston

02118

RECRUITING

Boston Medical Center, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Massachusetts General Hospital

OTHER