30
Participants
Start Date
August 1, 2026
Primary Completion Date
July 31, 2031
Study Completion Date
December 31, 2031
MagniXene, hyperpolarized 129Xe MRI
"All subjects will undergo hyperpolarized 129-Xenon MR imaging (HP MRI) and conventional proton MR imaging of lung. Hyperpolarized 129Xe gas is prepared in a process termed spin-exchange optical pumping.~Xenon is highly lipophilic and therefore soluble in blood and tissue, making it an excellent tool for imaging the gas in both the air spaces (gas-phase imaging) and dissolved in the lung parenchyma (dissolved-phase imaging). This solubility in combination with xenon's chemical shift properties, results in the possibility of quantifying pulmonary gas exchange and gas transport within the parenchyma.~Additionally, previous images and lung function tests will be reviewed to compare findings and evaluate if there is a correlation between the obtained results."
University of Pennsylvania, Philadelphia
Children's Hospital of Philadelphia
OTHER
Xemed LLC
INDUSTRY