Optimal Anti-EGFR Treatment of mCRC Patients With Low-Frequency RAS Mutation

"Panitumumab 6 mg/kg BW as 60-min i.v. infusion\* D1~\*If the 1st infusion is well tolerated, all subsequent infusions can be applied over 30-60 minutes."

Irinotecan 180 mg/m² BSA i.v., 30 - 90 min D1

Folinic acid (racemic) 400 mg/m²BSA i.v., 120 min D1

5-FU 400 mg/m² BSA, bolus, D1 5-FU 2400 mg/m² BSA i.v. infusion over a period of 46 h D1-2