A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

461

Participants

Timeline

Start Date

November 5, 2019

Primary Completion Date

July 26, 2023

Study Completion Date

July 30, 2027

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
BIOLOGICAL

Nivolumab

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days

DRUG

Cisplatin

Specified dose on specified days

DRUG

Paclitaxel

Specified dose on specified days

DRUG

Pemetrexed

Specified dose on specified days

DRUG

Placebo

Specified dose on specified days

DRUG

Docetaxel

Specified dose on specified days

Trial Locations (108)

235

Local Institution - 0116, New Taipei City

807

Local Institution - 0149, Kaohsiung City

833

Local Institution - 0119, Kaohsiung City

1426

Local Institution - 0030, CABA

1431

Local Institution - 0032, Ciudad Autonoma Beunos Aires

2050

Local Institution - 0020, Sydney

2650

Local Institution - 0002, Edegem

3065

Local Institution - 0122, Melbourne

3084

Local Institution - 0033, Heidelberg

4000

Local Institution - 0005, Liège

8800

Local Institution - 0001, Roeselare

13353

Local Institution - 0085, Berlin

20122

Local Institution - 0026, Milan

20817

Rcca Md Llc, Bethesda

22408

Local Institution - 0103, Fredericksburg

23538

Local Institution - 0063, Lübeck

25030

Local Institution - 0073, Besançon

28006

Local Institution - 0046, Madrid

28222

Local Institution - 0044, Majadahonda - Madrid

30342

Local Institution - 0040, Atlanta

30912

Local Institution - 0120, Augusta

31000

Local Institution - 0028, Chihuahua City

33500

Local Institution - 0023, North Ballarat

33612

Local Institution - 0104, Tampa

34295

Local Institution - 0050, Montpellier

35033

Local Institution - 0083, Rennes

38700

Local Institution - 0037, La Tronche

43126

Local Institution - 0025, Parma

44106

Local Institution - 0102, Cleveland

44280

Local Institution - 0077, Guadalajara

45220

Local Institution - 0055, Cincinnati

46026

Local Institution - 0045, Valencia

47014

Local Institution - 0024, Forlì

47441

Local Institution - 0070, Moers

49124

Local Institution - 0072, Georgsmarienhütte

49684

Local Institution - 0086, Traverse City

51109

Local Institution - 0110, Cologne

59063

Local Institution - 0071, Hamm

60462

Local Institution - 0121, Orland Park

60488

Local Institution - 0065, Frankfurt

60611

Local Institution - 0145, Chicago

60612

Local Institution - 0078, Chicago

64460

Local Institution - 0027, Monterrey

69126

Local Institution - 0108, Heidelberg

71640

Local Institution - 0147, Ludwigsburg

74245

Local Institution - 0064, Löwenstein

75018

Local Institution - 0038, Paris

75970

Local Institution - 0051, Paris

76000

Local Institution - 0146, Rouen

77030

Local Institution - 0054, Houston

81675

Local Institution - 0066, München

87509

Local Institution - 0109, Immenstadt im Allgäu

100021

Local Institution - 0115, Beijing

100142

Local Institution - 0096, Beijing

100225

Local Institution - 0112, Taipei

115478

Local Institution, Moscow

194291

Local Institution, Saint Petersburg

197758

Local Institution, Saint Petersburg

198255

Local Institution, Saint Petersburg

200010

Local Institution - 0098, Shanghai

200030

Local Institution - 0165, Shanghai

200032

Local Institution - 0095, Shanghai

200433

Local Institution - 0113, Shanghai

310016

Local Institution - 0099, Hangzhou

350001

Local Institution - 0137, Fuzhou

350014

Local Institution - 0136, Fuzhou

400015

Local Institution - 0013, Cluj-Napoca

407280

Local Institution - 0012, Floreşti

410000

Local Institution - 0092, Changsha

Local Institution - 0093, Changsha

410008

Local Institution - 0091, Changsha

430079

Local Institution - 0151, Hubei Sheng

610041

Local Institution - 0088, Chengdu

1040045

Local Institution - 0143, Chuo-ku

1138431

Local Institution - 0142, Bunkyo-ku

1138603

Local Institution - 0133, Bunkyo-ku

2778577

Local Institution - 0124, Kashiwa-shi

3620806

Local Institution - 0130, Kitaadachigun

4640021

Local Institution - 0135, Nagoya

5418567

Local Institution - 0134, Chuo-ku

5918555

Local Institution - 0126, Sakai-shi

6500047

Local Institution - 0127, Kobe

8078556

Local Institution - 0129, Kitakyushu-shi

9208641

Local Institution - 0144, Kanazawa

9800873

Local Institution - 0131, Sendai

02215

Local Institution - 0076, Boston

02459

Local Institution - 0074, Newton

03756

Local Institution - 0100, Lebanon

C1199ABB

Local Institution - 0031, ABB

CP1280AEB

Local Institution - 0043, Buenos Aires

30130-090

Local Institution - 0035, Belo Horizonte

98700-000

Local Institution - 0029, Ijuí

01509-010

Local Institution - 0036, São Paulo

05652-900

Local Institution - 0034, São Paulo

01321-001

Local Institution - 0106, São Paulo

L1G 2B9

Local Institution - 0062, Oshawa

128 08

Local Institution - 0041, Prague

140 59

Local Institution - 0042, Prague

D24 DH74

Local Institution - 0016, Dublin

241-8515

Local Institution - 0125, Yokohama

960-1295

Local Institution - 0132, Fukushima

734-8551

Local Institution - 0128, Hiroshima

9700RB

Local Institution - 0004, Groningen

3015 GD

Local Institution - 0003, Rotterdam

31-202

Local Institution - 0049, Krakow

00917

Local Institution - 0117, Hato Rey

022328

Local Institution - 0011, Bucharest

TA1 5DA

Local Institution - 0007, Taunton

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY