NCT04023227 - Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC | Biotech Hunter

Enrollment

918

Participants

Timeline

Start Date

December 10, 2019

Primary Completion Date

March 16, 2025

Study Completion Date

March 31, 2025

Conditions

Chagas DiseaseHeart Failure

Interventions

DRUG

Sacubitril/valsartan

50 (24/26) mg, 100 (49/51) mg and 200 (97/103) mg will be available for dose adjustments.

DRUG

Enalapril

5 mg and 10 mg will be available for dose adjustments.

Trial Locations (82)

1604

Novartis Investigative Site, San Martín

1834

Novartis Investigative Site, Temperley

2000

Novartis Investigative Site, Rosario

14080

Novartis Investigative Site, Ciudad de

30360

Novartis Investigative Site, Santa Marta

68000

Novartis Investigative Site, Oaxaca City

91193

Novartis Investigative Site, Xalapa

97000

Novartis Investigative Site, Mérida

110111

Novartis Investigative Site, Bogota DC

110121

Novartis Investigative Site, Bogota

681001

Novartis Investigative Site, Florida Blanca

681004

Novartis Investigative Site, Floridablanca

684031

Novartis Investigative Site, San Gil

40110060

Novartis Investigative Site, Salvador

70673623

Novartis Investigative Site, Brasila

C1221ADC

Novartis Investigative Site, CABA

C1425BEI

Novartis Investigative Site, CABA

B1704ETD

Novartis Investigative Site, Ramos Mejía

X5900JKA

Novartis Investigative Site, Villa María

A4406BPF

Novartis Investigative Site, Salta

T4000ICL

Novartis Investigative Site, San Miguel de Tucumán

S2000DIF

Novartis Investigative Site, Rosario

T4000IFL

Novartis Investigative Site, San Miguel de Tucumán

T4000JCU

Novartis Investigative Site, San Miguel de Tucumán

C1155 AHD

Novartis Investigative Site, Buenos Aires

C1425AGP

Novartis Investigative Site, Buenos Aires

W3400

Novartis Investigative Site, Corrientes

X5003DCE

Novartis Investigative Site, Córdoba

X5004BAL

Novartis Investigative Site, Córdoba

X5006CBI

Novartis Investigative Site, Córdoba

X5016KET

Novartis Investigative Site, Córdoba

P3600

Novartis Investigative Site, Formosa

P3634XAR

Novartis Investigative Site, Formosa

M5500CHC

Novartis Investigative Site, Mendoza

S3000EOZ

Novartis Investigative Site, Santa Fe

S3000FWO

Novartis Investigative Site, Santa Fe

G4200AQK

Novartis Investigative Site, Santiago del Estero

60430 370

Novartis Investigative Site, Fortaleza

40050-410

Novartis Investigative Site, Salvador

40323-010

Novartis Investigative Site, Salvador

41253-190

Novartis Investigative Site, Salvador

70390-903

Novartis Investigative Site, Brasília

70710-100

Novartis Investigative Site, Brasília

74223-060

Novartis Investigative Site, Goiânia

74223-130

Novartis Investigative Site, Goiânia

74605-020

Novartis Investigative Site, Goiânia

65020-070

Novartis Investigative Site, São Luís

30130-100

Novartis Investigative Site, Belo Horizonte

30140 062

Novartis Investigative Site, Belo Horizonte

30150-270

Novartis Investigative Site, Belo Horizonte

39401-001

Novartis Investigative Site, Montes Claros

37904-020

Novartis Investigative Site, Passos

38025-440

Novartis Investigative Site, Uberaba

38400 500

Novartis Investigative Site, Uberlândia

38400-328

Novartis Investigative Site, Uberlândia

86038-440

Novartis Investigative Site, Londrina

66087-660

Novartis Investigative Site, Belém

50100-060

Novartis Investigative Site, Recife

64001-380

Novartis Investigative Site, Teresina

20551-030

Novartis Investigative Site, Rio de Janeiro

22240-006

Novartis Investigative Site, Rio de Janeiro

59020-035

Novartis Investigative Site, Natal

3880-1001

Novartis Investigative Site, Botucatu

13183-091

Novartis Investigative Site, Bragança Paulista

13020-431

Novartis Investigative Site, Campinas

13060 080

Novartis Investigative Site, Campinas

13060-904

Novartis Investigative Site, Campinas

13330-570

Novartis Investigative Site, Indaiatuba

17515-000

Novartis Investigative Site, Marília

14010-190

Novartis Investigative Site, Ribeirão Preto

14048-900

Novartis Investigative Site, Ribeirão Preto

09080-001

Novartis Investigative Site, Santo André

15015-210

Novartis Investigative Site, São José do Rio Preto

15015-750

Novartis Investigative Site, São José do Rio Preto

15090-000

Novartis Investigative Site, São José do Rio Preto

04012 909

Novartis Investigative Site, São Paulo

05403-000

Novartis Investigative Site, São Paulo

18270-170

Novartis Investigative Site, Tatuí

15500 003

Novartis Investigative Site, Votuporanga

98700-000

Novartis Investigative Site, Ijuí

01223-001

Novartis Investigative Site, São Paulo