Treatment of Hemophilia A Patients With FVIII Inhibitors

RecruitingOBSERVATIONAL
Enrollment

120

Participants

Timeline

Start Date

March 17, 2020

Primary Completion Date

December 31, 2028

Study Completion Date

June 30, 2029

Conditions
Hemophilia A
Interventions
BIOLOGICAL

Nuwiq

Nuwiq is a recombinant FVIII concentrate from a human cell line. It is administered via intravenous injection at a dosage determined by the investigator's discretion, in consideration of the participants' clinical condition and prescribing information.

BIOLOGICAL

Octanate

Octanate is a high-purity human Factor VIII / von Willebrand Factor (VWF) concentrate. It is administered via intravenous injection at a dosage determined by the investigator's discretion, in consideration of the participants' clinical condition and prescribing information.

BIOLOGICAL

Wilate

Wilate is a high-purity human von Willebrand Factor (VWF)/Factor VIII concentrate. It is administered via intravenous injection at a dosage determined by the investigator's discretion, in consideration of the participants' clinical condition and prescribing information.

BIOLOGICAL

Emicizumab

Emicizumab is a therapeutic antibody which brings activated factor IX and factor X together It is administered via subcutaneous injection at a dosage determined by the investigator's discretion, in consideration of the participants' clinical condition and prescribing information.

BIOLOGICAL

Recombinant factor VIIa (rFVIIa)

Recombinant factor VIIa (rFVIIa) is a blood factor VII manufactured using recombinant technology. It is administered via intravenous injection at a dosage determined by the investigator's discretion, in consideration of the participants' clinical condition and prescribing information.

BIOLOGICAL

Activated prothrombin complex concentrate (aPCC)

Activated prothrombin complex concentrate (aPCC) is an anti-inhibitor coagulant complex acting on multiple pathways to facilitate coagulation. It is administered via intravenous injection at a dosage determined by the investigator's discretion, in consideration of the participants' clinical condition and prescribing information.

Trial Locations (2)

30329

RECRUITING

Arthur M. Blank Hospital, Atlanta

64546

RECRUITING

HZRM Hämophilie-Zentrum Rhein Main, Mörfelden-Walldorf

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Octapharma

INDUSTRY

lead

Emory University

OTHER

NCT04023019 - Treatment of Hemophilia A Patients With FVIII Inhibitors | Biotech Hunter | Biotech Hunter