NCT04022876 - A Study of ALRN-6924 for the Prevention of Chemotherapy-induced Side Effects (Chemoprotection) | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 3, 2019

Primary Completion Date

July 30, 2022

Study Completion Date

August 30, 2022

Conditions

Non Small Cell Lung CancerSmall-cell Lung Cancer

Interventions

DRUG

ALRN-6924

ALRN-6924 administered IV on Days 0-2 prior to carboplatin and pemetrexed administered IV on Day 1 of every 21-day cycle.

DRUG

Carboplatin

Carboplatin administered IV on Day 1 of every 21-day cycle.

DRUG

Pemetrexed

Pemetrexed administered IV on Day 1 of every 21-day cycle.

DRUG

Placebo

Placebo administered IV on Days 0-2 prior to carboplatin and pemetrexed administered IV on Day 1 of every 21-day cycle.

DRUG

ALRN-6924

ALRN-6924 administered IV on Days 0-4 prior to topotecan administered IV on Days 1-5 of every 21-day cycle.

DRUG

Topotecan

Topotecan administered IV on Days 1-5 of every 21-day cycle.

Trial Locations (28)

17325

Gettysburg Cancer Center, Gettysburg

27893

Regional Medical Oncolgy Center, Wilson

33140

Mount Sinai Cancer Research Program, Miami

33321

Oncology & Hematology Associates of West Broward, Tamarac

33612

H. Lee Moffitt Cancer Center & Research Institute, Tampa

44718

Gabrail Cancer Institute, Canton

86409

Arizona Cancer Center, Kingman

97210

OSHU CHO Northwest, Portland

Unknown

University Clinical Center of the Republic of Srpska, Lung Clinic, Banja Luka

Clinical Center University of Sarajevo, Oncology Clinic, Sarajevo

Charité Comprehensive Cancer Center Benjamin Franklin Hamato, Onkologische, Berlin

Universitaetsklinikum Heidelberg Thoraxklinik Heidelberg, Heidelberg

LMU Klinikum der Universitaet Muenchen, Respiratory Medicine and Thoracic Oncology, Campus Innenstandt, München

München Klinik Neuperlach, Klinik für Hamatologie und Onkologie, Studienburo Neuperlach/Harlaching, München

Istituto Romagnolo per lo Studio dei Tumori, Dino Amadori, Meldola

Azienda Ospedaliero, Universitaria di Modena, Policlinico di Modena, Modena

Istituto Nazionale Tumori di Napoli, IRCCS, Fondazione, G. Pascale, Napoli

Università degli Studi di Pavia, IRCCS, Fondazione, Policlinico San Matteo, Pavia

Azienda Unità Sanitaria Locale della Romagna, Ospedale Santa Maria delle Croci, Ravenna

Azienda Ospedaliera Universitaria Integrata Verona, Verona

Szpital Kliniczny Przemienienia Panskiego, Poznan

CHC Bezanijska Kosa, Belgrade

University Clinical Centre of Serbia, Pulmonology Clinic, Belgrade

Clinical Centre Nis, Clinic for Pulmonary Diseases, Niš

Institute for Pulmonary Diseases of Vojvodina, Novi Sad

Hospital Clinico San Carlos, Madrid

Hospital Universitario 12 de Octubre, Madrid

MD Anderson Cancer Center, Madrid