Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach

RecruitingOBSERVATIONAL
Enrollment

5,000

Participants

Timeline

Start Date

November 1, 2019

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2026

Conditions
Gastric CancerAtrophic GastritisGastric DysplasiaH.Pylori Infection
Interventions
DEVICE

Breath sampling for VOC detection

Breath sampling will be performed by using a special sensor device and or GC-MS analysis (by collecting breath samples in adsorbent tubes). Pepsinogen testing will be used in a subgroup to identify serological increased risk for atrophy

PROCEDURE

Surgery material collection for VOC headspace analysis

Only for gastric cancer patients undergoing surgery (Group 1)

DIAGNOSTIC_TEST

Upper endoscopy

Routine endoscopic evaluation with a standard biopsy work-up according to updated Sydney system. Additional gastric contents for GC-MS and microbiota analysis in a subgroup. Endoscopy will be used only according to the clinical indications (in Group 4 - according to the results of pepsinogen tests)

DIAGNOSTIC_TEST

Microbiota testing

Faecal and gastric contents and biopsy samples for microbiota testing

Trial Locations (5)

Unknown

RECRUITING

A.C.Camargo Cancer Center, São Paulo

NOT_YET_RECRUITING

Pontificia Universidad Catolica de Chile, Santiago

NOT_YET_RECRUITING

Centro Javeriano de Oncología, San Ignacio University Hospital, Bogotá

RECRUITING

National Cancer Institute of Ukraine, Kiev

LV1050

RECRUITING

Institute of Clinical and Preventive Medicine, University of Latvia, Riga

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Technion, Israel Institute of Technology

OTHER

collaborator

University of Ulm

OTHER

collaborator

Uppsala University

OTHER

collaborator

JLM Innovation GmbH

UNKNOWN

collaborator

Universitaet Innsbruck

OTHER

collaborator

Hospital Universitario San Ignacio

OTHER

collaborator

Universidad de Pamplona

OTHER

collaborator

Pontificia Universidad Catolica de Chile

OTHER

collaborator

AC Camargo Cancer Center

OTHER

collaborator

National Cancer Institute of Ukraine

OTHER

collaborator

VTT Technical Research Centre of Finland

OTHER

lead

University of Latvia

OTHER

NCT04022109 - Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach | Biotech Hunter | Biotech Hunter