Machine Learning Modeling of Intraoperative Hemodynamic Predictors of Postoperative Outcomes

CompletedOBSERVATIONAL
Enrollment

35,000

Participants

Timeline

Start Date

January 1, 2013

Primary Completion Date

December 31, 2017

Study Completion Date

December 31, 2017

Conditions
Perioperative/Postoperative ComplicationsMorbidity, MultipleSurgeryAnesthesiaDeath
Interventions
OTHER

Blood pressure

"Systolic Blood Pressure (SBP)~1. Maximum change from preoperative SBP, in a) absolute change (mmHg), and b) relative change (%)(emergency and elective cases analyzed separately)~2. Cumulative duration (minutes) \>=20% below preoperative SBP~3. Longest single episode (minutes) below a) 80, b) 90, and c)100 mmHg~4. Cumulative duration (minutes) below a) 80, b) 90, and c)100 mmHg~Mean Arterial Pressure (MAP)~1. Maximum change from preoperative MAP, in a) absolute change (mmHg), and b) relative change (%) (emergency and elective cases analyzed separately)~2. Cumulative duration (minutes) \>=20% below preoperative MAP~3. Longest single episode (minutes) below a) 60, b) 65, c) 70, and d) 80mmHg~4. Cumulative duration (minutes) below a) 60, b) 65, c) 70, and d) 80mmHg"

OTHER

Heart rate

"1. Maximum change (beats per minute, BPM) from preoperative heart rate (positive and negative)~2. Relative change (%) from preoperative heart rate (positive and negative)~3. Maximum pulse variation (maximum heart rate minus minimum heart rate)~4. Longest single episode (minutes) a) below 60, and b) above 100BPM~5. Cumulative duration (minutes) a) below 60, and b) above 100BPM"

OTHER

Use of hemodynamic medications (i.e. special medications for blood pressure)

"1. Vasopressor/inotrope use (yes vs. no): phenylephrine, norepinephrine, epinephrine, vasopressin, dobutamine, or milrinone~2. Infusion of any vasopressor/inotropes above (yes vs. no) (identified by unit of weight over time)~3. Phenylephrine/ephedrine bolus (yes vs. no) (identified by unit of weight only)~4. Vasodilator use (yes vs. no): labetalol, esmolol, nitroglycerin, nitroprusside~5. Infusion of any vasodilator above (yes vs. no) (identified by unit of weight over time)"

OTHER

Oxygen saturation by pulse oximetry (SpO2)

"1. Longest single episode (minutes) below a) 88, and b) 90%~2. Cumulative duration (minutes) below a) 88, and b) 90%"

OTHER

End-tidal Carbon dioxide (EtCO2)

"1. Longest single episode (minutes) a) below 30, and b) above 45mmHg~2. Cumulative duration (minutes) a) below 30, and b) above 45mmHg"

All Listed Sponsors
collaborator

Dalhousie University

OTHER

collaborator

Harvard University

OTHER

collaborator

University of Toronto

OTHER

collaborator

University of Ottawa

OTHER

lead

Janny Xue Chen Ke

OTHER

NCT04014010 - Machine Learning Modeling of Intraoperative Hemodynamic Predictors of Postoperative Outcomes | Biotech Hunter | Biotech Hunter