A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

839

Participants

Timeline

Start Date

August 5, 2019

Primary Completion Date

August 28, 2024

Study Completion Date

June 10, 2026

Conditions
Metastatic Colorectal Cancer
Interventions
BIOLOGICAL

Ipilimumab

Specified dose on specified days

DRUG

Oxaliplatin

Specified dose on specified days

DRUG

Leucovorin

Specified dose on specified days

DRUG

Fluorouracil

Specified dose on specified days

DRUG

Irinotecan

Specified dose on specified days

DRUG

Bevacizumab

Specified dose on specified days

DRUG

Cetuximab

Specified dose on specified days

BIOLOGICAL

Nivolumab

Specified dose on specified days

Trial Locations (157)

1070

Local Institution - 0025, Anderlecht

1090

Local Institution - 0065, Vienna

1093

Local Institution - 0084, Buenos Aires

1199

Local Institution - 0100, CABA

1426

Local Institution - 0072, CABA

1431

Local Institution - 0073, Ciudad Autonoma Beunos Aires

1478

Local Institution - 0034, Lorenskog

2145

Local Institution - 0019, Westmead

2700

Local Institution - 0067, Wiener Neustadt

2730

Local Institution - 0038, Herlev

2820

Local Institution - 0045, Bonheiden

3000

Local Institution - 0024, Leuven

3084

Local Institution - 0017, Heidelberg

3168

Local Institution - 0041, Clayton

4010

Local Institution - 0068, Linz

4102

Local Institution - 0053, Woolloongabba

5020

Local Institution - 0120, Salzburg

5021

Local Institution - 0033, Bergen

5112

Local Institution - 0018, Elizabeth Vale

7100

Local Institution - 0036, Vejle

8036

Local Institution - 0064, Graz

8500

Local Institution - 0074, Viedma

10065

Local Institution - 0060, New York

11525

Local Institution - 0222, Athens

11528

Local Institution - 0123, Athens

13005

Local Institution - 0066, Marseille

15006

Local Institution - 0173, A Coruña

15232

Local Institution - 0121, Pittsburgh

15562

Local Institution - 0124, Cholargós

16132

Local Institution - 0003, Genova

20162

Local Institution - 0001, Milan

20249

Local Institution - 0043, Hamburg

22763

Local Institution - 0117, Hamburg

24014

Local Institution - 0104, Roanoke

25030

Local Institution - 0028, Besançon

28041

Local Institution - 0005, Madrid

29010

Local Institution - 0172, Málaga

30625

Local Institution - 0008, Hanover

31059

Local Institution - 0040, Toulouse

33604

Local Institution - 0061, Pessac

34298

Local Institution - 0030, Montpellier

34300

Local Institution - 0101, Istanbul

35043

Local Institution - 0044, Marburg

35128

Local Institution - 0002, Padua

41013

Local Institution - 0063, Seville

44093

Local Institution - 0032, Nantes

45122

Local Institution - 0007, Essen

45500

Local Institution - 0126, Ioannina

46014

Local Institution - 0171, Valencia

59000

Local Institution - 0138, Lille

60005

Local Institution - 0119, Arlington Heights

64109

Local Institution - 0186, Bayonne

67200

Local Institution - 0184, Strasbourg

69008

Local Institution - 0183, Lyon

69120

Local Institution - 0009, Heidelberg

69373

Local Institution - 0029, Lyon

71110

Local Institution - 0125, Heraklion

75012

Local Institution - 0027, Paris

75246

Local Institution - 0106, Dallas

80131

Local Institution - 0004, Napoli

80218

Local Institution - 0103, Denver

81377

Local Institution - 0010, Munich

86000

Local Institution - 0031, Poitiers

87042

Local Institution - 0176, Limoges

90033

Local Institution - 0059, Los Angeles

95122

Local Institution - 0055, Catania

95817

Local Institution - 0130, Sacramento

97227

Local Institution - 0105, Portland

110042

Local Institution - 0162, Shenyang

130021

Local Institution - 0164, Changchun

150040

Local Institution - 0180, Harbin

200080

Local Institution - 0143, Shanghai

200120

Local Institution - 0131, Shanghai

200131

Local Institution - 0221, Shanghai

200542

Local Institution - 0081, Craiova

213003

Local Institution - 0145, Changzhou

230061

Local Institution - 0146, Hefei

250117

Local Institution - 0210, Jinan

264000

Local Institution - 0165, Yantai

266061

Local Institution - 0154, Qingdao

276001

Local Institution - 0212, Linyi

310009

Local Institution - 0137, Hangzhou

315041

Local Institution - 0206, Ningbo

330006

Local Institution - 0151, Nanchang

361003

Local Institution - 0163, Xiamen

363000

Local Institution - 0207, Zhangzhou

400015

Local Institution - 0076, Cluj-Napoca

410013

Local Institution - 0197, Changsha

450052

Local Institution - 0181, Zhengzhou

510080

Local Institution - 0167, Guangzhou

510095

Local Institution - 0153, Guangzhou

510655

Local Institution - 0149, Guangzhou

528000

Local Institution - 0158, Foshan

530000

Local Institution - 0160, Nanning

530021

Local Institution - 0196, Nanning

650106

Local Institution - 0195, Kunming

700483

Local Institution - 0205, Iași

710126

Local Institution - 0188, Xi'an

720237

Local Institution - 0089, Suceava

730030

Local Institution - 0211, Lanzhou

1040045

Local Institution - 0118, Chuo-ku

1058470

Local Institution - 0129, Minato-ku

2778577

Local Institution - 0107, Kashiwa-shi

4118777

Local Institution - 0108, Sunto-gun

4648681

Local Institution - 0109, Nagoya

7108602

Local Institution - 0177, Kurashiki

7500921

Local Institution - 0071, Santiago

8111395

Local Institution - 0116, Fukuoka

8320000

Local Institution - 0069, Santiago

8608556

Local Institution - 0133, Kumamoto

9208641

Local Institution - 0128, Kanazawa

9896183

Local Institution - 0189, Ōsaki

15090000

Local Institution - 0094, São José do Rio Preto

35160-158

Local Institution - 0096, Ipatinga

59075-740

Local Institution - 0200, Natal

91350-200

Local Institution - 0192, Porto Alegre

14780-070

Local Institution - 0102, Barretos

01509-010

Local Institution - 0095, São Paulo

20231-050

Local Institution - 0199, Rio de Janeiro

01246-000

Local Institution - 0193, São Paulo

T6G 1Z2

Local Institution - 0011, Edmonton

V5Z 4E6

Local Institution - 0039, Vancouver

M5G 1X5

Local Institution - 0013, Toronto

H2X 3E4

Local Institution - 0016, Montreal

J1H 5N4

Local Institution - 0015, Sherbrooke

Unknown

Local Institution - 0070, Independencia

Local Institution - 0091, Dublin

Local Institution - 0022, Dublin

656 53

Local Institution - 0087, Brno

500 05

Local Institution - 0085, Hradec Králové

741 01

Local Institution - 0088, Nový Jičín

779 00

Local Institution - 0086, Olomouc

01307

Local Institution - 0042, Dresden

V94 F858

Local Institution - 0026, Limerick

00168

Local Institution - 0054, Roma

260-8717

Local Institution - 0112, Chiba

791-0280

Local Institution - 0132, Matsuyama

0608648

Local Institution - 0174, Sapporo

216-8511

Local Institution - 0111, Kawasaki

241-8515

Local Institution - 0175, Yokohama

565-0871

Local Institution - 0115, Suita-shi

350-1298

Local Institution - 0187, Hidaka

362-0806

Local Institution - 0110, Kitaadachigun

135-8550

Local Institution - 0113, Koto-ku

540-0006

Local Institution - 0114, Osaka

1066 CX

Local Institution - 0052, Amsterdam

1081 HV

Local Institution - 0051, Amsterdam

3584 CX

Local Institution - 0050, Utrecht

0450

Local Institution - 0035, Oslo

00935

Local Institution - 0058, Rio Piedras

002200

Local Institution - 0168, Brasov

022328

Local Institution - 0080, Bucharest

08916

Local Institution - 0056, Badalona

08035

Local Institution - 0006, Barcelona

01060

Local Institution - 0092, Adana

EC1A 7BE

Local Institution - 0127, London

OX3 7LE

Local Institution - 0049, Oxford

Sponsors
All Listed Sponsors
collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY