Study of Platinum Plus Etoposide With or Without Tislelizumab in Participants With Untreated Extensive-Stage Small Cell Lung Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

457

Participants

Timeline

Start Date

July 22, 2019

Primary Completion Date

April 19, 2023

Study Completion Date

December 29, 2023

Conditions
Small Cell Lung Cancer
Interventions
DRUG

Tislelizumab

200 mg administered intravenously on Day 1 of each 21-day cycle

DRUG

Cisplatin

75 mg/m² was administered intravenously on Day 1 of each 21-day cycle, infused over a duration of two hours. Treatment with cisplatin was discontinued starting in Cycle 5 and beyond.

DRUG

Carboplatin

An area under the curve (AUC) of 5 mg/mL/min was administered intravenously on Day 1 of each 21-day cycle, infused over a duration of 15 to 60 minutes. Treatment with carboplatin was discontinued starting in Cycle 5 and beyond.

DRUG

Etoposide

100 mg/m² was administered intravenously from Day 1 to Day 3 of each 21-day cycle, infused over a duration of 60 minutes. Treatment with etoposide was discontinued starting in Cycle 5 and beyond.

DRUG

Placebo

200 mg was administered intravenously on Day 1 of each 21-day cycle to match tislelizumab.

Trial Locations (50)

100000

Peking University Third Hospital, Beijing

100029

China Japan Friendship Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

100730

Beijing Hospital, Beijing

Peking Union Medical College Hospital, Beijing

100853

Chinese Pla General Hospital, Beijing

102206

Peking University International Hospital, Beijing

110001

The First Hospital of China Medical University, Shenyang

110042

Liaoning Cancer Hospital and Institute, Shenyang

130021

Jilin Cancer Hospital, Changchun

150000

Harbin Medical University Cancer Hospital, Harbin

200030

Shanghai Chest Hospital, Shanghai

200433

Shanghai Pulmonary Hospital, Shanghai

210002

General Hospital of Eastern Theater Command, Nanjing

210029

Nanjing Chest Hospital, Nanjing

215006

The First Affiliated Hospital of Soochow University, Suzhou

230601

The Second Hospital of Anhui Medical University, Hefei

250013

Jinan Central Hospital, Jinan

250117

Shandong Cancer Hospital, Jinan

264000

Yantai Yuhuangding Hospital, Yantai

266000

The Affiliated Hospital of Qingdao University Branch South, Qingdao

300052

Tianjin Medical University General Hospital, Tianjin

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310003

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

350001

Fujian Medical University Union Hospital, Fuzhou

350014

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

400042

Daping Hospital, Third Military Medical University, Chongqing

410004

Changsha Central Hospital, Changsha

410008

Xiangya Hospital of Central South University, Changsha

410013

Hunan Cancer Hospital, Changsha

430014

Wuhan Central Hospital, Wuhan

430022

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan

450000

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510030

Cancer Center of Guangzhou Medical University, Guangzhou

510080

Guangdong Provincial Peoples Hospital, Guangzhou

510120

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

530021

The Peoples Hospital of Guangxi Zhuang Autonomous Region, Nanning

The Tumor Hospital Affiliated to Guangxi Medical University, Nanning

541001

Affiliated Hospital of Guilin Medical University, Guilin

610041

Sichuan Cancer Hospital and Institute, Chengdu

West China Hospital, Sichuan University, Chengdu

650100

Yunnan Cancer Hospital, Kunming

710061

Shaanxi Provincial Cancer Hospital, Xi'an

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

730000

The First Hospital of Lanzhou University, Lanzhou

830000

Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY