Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

February 17, 2020

Primary Completion Date

April 7, 2022

Study Completion Date

September 30, 2025

Conditions
Urothelial Carcinoma
Interventions
DRUG

Avelumab

Avelumab: 800 mg IV every two weeks (on days 1 and 15 of a 28-day cycle)

DRUG

AVB-S6-500

AVB-S6-500: 10mg/kg IV every 2 weeks (on days 1 and 15 of a 28-day cycle) Potential dose reduction: AVB-S6-500: 5mg/kg IV weekly (on days 1, 8, 15 and 22 of a 28-day cycle)

Trial Locations (1)

73104

Stephenson Cancer Center, Oklahoma City

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Aravive, Inc.

INDUSTRY

collaborator

EMD Serono

INDUSTRY

lead

University of Oklahoma

OTHER

NCT04004442 - Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma | Biotech Hunter | Biotech Hunter