A Study of SHP655 (rADAMTS13) in Sickle Cell Disease

PHASE1CompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

October 21, 2019

Primary Completion Date

October 26, 2022

Study Completion Date

October 26, 2022

Conditions
Sickle Cell Disease
Interventions
DRUG

TAK-755

Participants will receive TAK-755 as a single IV infusion at one of the 3 dose levels of 40 IU/kg, 80 IU/kg, or 160 IU/kg.

OTHER

Placebo

Participants will receive placebo matched to TAK-755 of the 3 dose levels of 40 IU/kg, 80 IU/kg, and 160 IU/kg as single IV infusion.

Trial Locations (14)

21218

Johns Hopkins University School Of Medicine, Baltimore

23298

VCU Health - Research Parent, Richmond

27705

Duke University Medical Center, Durham

27858

East Carolina University, Greenville

28204

Levine Cancer Institute, Charlotte

29425

Medical University of South Carolina (MUSC), Charleston

35233

University of Alabama at Birmingham, Birmingham

43210

Ohio State University Medical Center, Columbus

70121

Ochsner Health System, New Orleans

77202

Arkansas Children's Hospital, Little Rock

80045

University of Colorado Sickle Cell Treatment and Research Center, Aurora

80262

Sickle Cell Center, Denver

60612-4325

University of Illinois, Chicago

38163-2116

University of Tennessee -- Memphis, Memphis

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Takeda Development Center Americas, Inc.

INDUSTRY

lead

Shire

INDUSTRY