120
Participants
Start Date
November 7, 2019
Primary Completion Date
October 10, 2025
Study Completion Date
October 10, 2025
Smoking Cessation Cognitive Behavioral Therapy (CBT)
12 sessions of cognitive behavioral therapy for smoking cessation, designed to help participants prepare for quitting smoking, make a quit attempt, and stay quit from smoking.
Bupropion
All medically eligible participants will be prescribed bupropion to begin 7 days before the quit date and continued through 12 weeks post-quit. Participants will be scheduled to begin at 150mg/day of bupropion for at least 3 days before titrating up to 300mg/day dose of bupropion.
Cognitive Processing Therapy
12 sessions of CPT, which is a well-established trauma-focused psychotherapy for PTSD that has demonstrated efficacy and effectiveness in Veterans.
Smoking Abstinence Reinforcement Therapy
Monetary reinforcement for smoking abstinence that is bioverified by breath carbon monoxide and saliva samples.
Yoked Contingency Management
Participants in the yoked control will receive the monetary reinforcement of their yoked participant regardless of smoking abstinence or session attendance.
Durham VA Medical Center, Durham, NC, Durham
VA Office of Research and Development
FED