CPT-SMART for Treatment of PTSD and Cigarette Smoking

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 7, 2019

Primary Completion Date

October 10, 2025

Study Completion Date

October 10, 2025

Conditions
SmokingStress Disorders, Post-Traumatic
Interventions
BEHAVIORAL

Smoking Cessation Cognitive Behavioral Therapy (CBT)

12 sessions of cognitive behavioral therapy for smoking cessation, designed to help participants prepare for quitting smoking, make a quit attempt, and stay quit from smoking.

DRUG

Bupropion

All medically eligible participants will be prescribed bupropion to begin 7 days before the quit date and continued through 12 weeks post-quit. Participants will be scheduled to begin at 150mg/day of bupropion for at least 3 days before titrating up to 300mg/day dose of bupropion.

BEHAVIORAL

Cognitive Processing Therapy

12 sessions of CPT, which is a well-established trauma-focused psychotherapy for PTSD that has demonstrated efficacy and effectiveness in Veterans.

BEHAVIORAL

Smoking Abstinence Reinforcement Therapy

Monetary reinforcement for smoking abstinence that is bioverified by breath carbon monoxide and saliva samples.

BEHAVIORAL

Yoked Contingency Management

Participants in the yoked control will receive the monetary reinforcement of their yoked participant regardless of smoking abstinence or session attendance.

Trial Locations (1)

27705-3875

Durham VA Medical Center, Durham, NC, Durham

All Listed Sponsors
lead

VA Office of Research and Development

FED