Ocrelizumab for Psychosis by Autoimmunity

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

October 1, 2019

Primary Completion Date

June 30, 2025

Study Completion Date

October 30, 2025

Conditions
Schizo-Affective Type of PsychosisSchizophrenia
Interventions
BEHAVIORAL

Psychosis and cognitive assessments

Administration of MINI, PANSS and Quality of Living scales

BEHAVIORAL

Physical and neuro-cognitive evaluations

Physical, neurological and cognitive evaluations.

DIAGNOSTIC_TEST

Safety labs and electrocardiogram

Metabolic panel, CBC and differential, urinalysis, ECG, recreational drugs. CD19+ B-cell count.

BIOLOGICAL

Ocrelizumab infusion

Two IV infusions of 300 mg of ocrelizumab 2 weeks apart

Trial Locations (1)

77030

RECRUITING

Houston Methodist Research Institute, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

The Methodist Hospital Research Institute

OTHER

NCT03971487 - Ocrelizumab for Psychosis by Autoimmunity | Biotech Hunter | Biotech Hunter