A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

September 30, 2019

Primary Completion Date

April 4, 2023

Study Completion Date

April 4, 2023

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Tivozanib

Dose level 1: 1.0mg for 21 days followed by 7 days rest; Dose level -1: 1.0mg every other day

DRUG

Durvalumab

1500mg every 28 days

Trial Locations (10)

10467

Montefiore Medical Center, The Bronx

14263

Roswell Park Cancer Institute, Buffalo

60611

Northwestern University Feinberg School of Medicine, Chicago

75390

UT Southwestern Medical Center, Dallas

75708

The University of Texas Health Science Center at Tyler (UTHealth), Tyler

77030

The University of Texas Health Science Center at Houston (UTHealth), Houston

85234

Banner MD Anderson Cancer Center, Gilbert

91010

City of Hope, Duarte

92868

University of California - Irvine, Orange

02215

Dana Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

AVEO Pharmaceuticals, Inc.

INDUSTRY