MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

114

Participants

Timeline

Start Date

September 29, 2019

Primary Completion Date

September 20, 2023

Study Completion Date

December 22, 2028

Conditions
Plexiform NeurofibromaNeurofibromatosis Type 1 (NF1)
Interventions
DRUG

Mirdametinib (PD-0325901) oral capsule or dispersible tablet

Mirdametinib (PD-0325901) capsule or dispersible tablet

Trial Locations (50)

10467

Children's Hospital at Montefiore, The Bronx

12208

Albany Medical Center, Albany

15224

Children's Hospital of Pittsburgh UPMC, Pittsburgh

19803

Nemours A. I. duPont Hospital for Children, Wilmington

20010

Children's National Medical Center, Washington D.C.

22903

UVA Health, Division of Neuro-Oncology, Charlottesville

23510

Children's Hospital of The King's Daughters, Norfolk

27514

UNC Medical Center, Chapel Hill

27710

Duke University Medical Center, Durham

30329

Children's Healthcare of Atlanta - Center for Advanced Pediatrics, Atlanta

32610

University of Florida Clinical Research Center, Gainesville

32804

AdventHealth Pediatric Oncology Hematology at Orlando, Orlando

32806

Orlando Health, Inc., Orlando

33155

Nicklaus Children's Hospital, Miami

33612

Moffitt Cancer Center, Tampa

33701

Johns Hopkins All Children's Hospital, St. Petersburg

35233

University of Alabama at Birmingham/Children's of Alabama, Birmingham

37232

Henry-Joyce Cancer Clinic, Nashville

40202

Kosair Charities Pediatric Clinical Research Unit, Louisville

43205

Nationwide Children's Hospital, Columbus

44195

Cleveland Clinic Foundation, Cleveland

45219

University of Cincinnati Medical Center, Cincinnati

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

IU Health Brain Tumor Infusion Clinic, Indianapolis

48109

University of Michigan CS Mott Children's Hospital, Ann Arbor

48202

Henry Ford Hospital, Detroit

52242

University of Iowa Hospitals & Clinics, Iowa City

53226

MACC Fund Research Center, Milwaukee

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

Mayo Clinic, Rochester

60612

University of Illinois Hospital and Health Systems, Chicago

60637

University of Chicago Medical Centers, Chicago

63110

Washington University School of Medicine-Siteman Cancer Center, St Louis

72202

Arkansas Children's Hospital, Little Rock

73104

University of Oklahoma Health Sciences Center, Jimmy Everest Center for Cancer and Blood Disorders in Children, Oklahoma City

75235

Children's Medical Center, Dallas

76104

Cook Children's Medical Center, Fort Worth

77030

The University of Texas MD Anderson Cancer Center, Houston

80045

Children's Hospital Colorado, Aurora

84108

University of Utah, Center for Clinical and Translational Sciences, Salt Lake City

85054

Mayo Clinic Hospital, Phoenix

90027

Children's Hospital Los Angeles, Los Angeles

90095

UCLA Oncology Center, Los Angeles

92868

Children's Hospital of Orange County, Orange

94304

Lucile Packard Children's Hospital Stanford, Palo Alto

95817

University of California - Davis Comprehensive Cancer Center, Sacramento

97239

Oregon Health and Science University, Portland

98122

Swedish Medical Center - Cherry Hill Campus, Seattle

92868-3201

University of California - Irvine Health, Orange

07503

St. Joseph's Univeristy Medical Center, Paterson

All Listed Sponsors
lead

SpringWorks Therapeutics, Inc.

INDUSTRY