Ultrasound for the Detection of Oxaliplatin-Induced Peripheral Neuropathy

Participants will undergo a serial and tibial nerve ultrasound

Two skin biopsies will be obtained as 4.0 mm punch biopsies at distal end of leg in sural nerve territory (10 cm above lateral malleolus) and from the thigh

Exam to include strength assessment of the tibialis anterior and gastrocnemius and deep tendon reflex exam of the Achilles on the limb to be examined by nerve conduction velocity and ultrasound.

12 ml blood sample will be taken

Sural and tibial nerve assessments

Self-reported neuropathy scoring questionnaire completed same day as blood draw.