A Study to Investigate Tislelizumab (BGB-A317) Versus Placebo in Combination With Concurrent Chemoradiotherapy in Participants With Localized Esophageal Squamous Cell Carcinoma

PHASE3CompletedINTERVENTIONAL
Enrollment

370

Participants

Timeline

Start Date

June 12, 2019

Primary Completion Date

March 31, 2025

Study Completion Date

March 31, 2025

Conditions
Esophageal Squamous Cell Carcinoma (ESCC)
Interventions
DRUG

Tislelizumab

Administrated at dose of 200 mg intravenously (IV)

DRUG

Placebo

Placebo to match tislelizumab

DRUG

Paclitaxel

Administered as 135 mg/m² IV injection

DRUG

Cisplatin

Administered as 25 mg/m² IV injection

RADIATION

Radiotherapy

Administered at a total dose of 50.4 Gy in 28 fractions

Trial Locations (33)

100021

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

100142

Beijing Cancer Hospital, Beijing

110042

Liaoning Cancer Hospital and Institute, Shenyang

150000

Harbin Medical University Cancer Hospital, Harbin

200000

Fudan University Shanghai Cancer Center, Shanghai

210029

Jiangsu Province Hospital, Nanjing

212001

Affiliated Hospital of Jiangsu University, Zhenjiang

213000

Changzhou Tumor(Fourth Peoples)Hospital, Changzhou

221000

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

222002

The First Peoples Hospital of Lianyungang, Lianyungang

225001

Northern Jiangsu Peoples Hospital, Yangzhou

250117

Shandong Cancer Hospital, Jinan

261000

Weifang Peoples Hospital, Weifang

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310002

Hangzhou Cancer Hospital, Hangzhou

310003

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

310016

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou

321000

Jinhua Municipal Central Hospital, Jinhua

350014

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

400030

Chongqing Cancer Hospital, Chongqing

410013

Hunan Cancer Hospital, Changsha

430022

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430079

Hubei Cancer Hospital, Wuhan

450000

Henan Cancer Hospital, Zhengzhou

453100

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

510000

The First Affiliated Hospitalschool of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou

522000

Jieyang Peoples Hospital (Jieyang Affiliated Hospital, Sun Yat Sen University ), Jieyang

610041

Sichuan Cancer Hospital and Institute, Chengdu

West China Hospital, Sichuan University, Chengdu

710061

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

010028

Inner Mongolia Autonomous Region Cancer Hospital, Hohhot

046000

Heping Hospital Affiliated to Changzhi Medical College, Changzhi

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT03957590 - A Study to Investigate Tislelizumab (BGB-A317) Versus Placebo in Combination With Concurrent Chemoradiotherapy in Participants With Localized Esophageal Squamous Cell Carcinoma | Biotech Hunter | Biotech Hunter