Study of Cabozantinib as 2nd Line Treatment in Subjects With Locally Advanced or Metastatic Renal Cell Carcinoma (RCC) With a Clear-Cell Component Who Progressed After 1st Line Treatment With Checkpoint Inhibitors

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

127

Participants

Timeline

Start Date

January 8, 2020

Primary Completion Date

May 11, 2023

Study Completion Date

December 30, 2030

Conditions
Locally Advanced or Metastatic Renal Cell Carcinoma
Interventions
DRUG

Cabozantinib

Oral tablets of 60mg, 40mg and 20 mg.

Trial Locations (40)

1011

Centre Hospitalier Universitaire Vaudois, Lausanne

3010

Universitätsspital Bern, Inselspital, Bern

9007

Kantonsspital St. Gallen, Sankt Gallen

13009

Institut Paoli Calmettes, Marseille

25000

CHRU Besançon, Besançon

27003

Hospital Lucus Augusti, Lugo

28033

M.D. Anderson Center Madrid, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

30029

CHU de Nîmes - Institut de Cancérologie du Gard, Nîmes

31059

Institut Claudius Régaud, Toulouse

44800

Institut de Cancérologie de l'Ouest, Saint-Herblain

54511

Institut de Cancérologie de Lorraine, Nancy

63011

Centre Jean Perrin, Clermont-Ferrand

67091

CHU Strasbourg, Strasbourg

69008

Centre Léon Bérard, Lyon

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

75014

Institut Mutualiste Montsouris, Paris

94805

Gustave Roussy, Villejuif

A-5020

SALK - Salzburger Landesklinik, Salzburg

D-10117

Universitätsmedzin Charité, Berlin

D-1307

University Hospital Carl Gustav Carus Dresden, Dresden

D-45147

Universitätsklinikum Essen, Essen

d-20246

University Cancer Center Hamburg Eppendorf, Hamburg

D-30625

Medizinische Hochschule Hannover, Hanover

D-07747

Klinikum Der Friedrich-Schiller-Universitaet Jena, Jena

D-23538

Universitätsklinikum Schleswig-Holstein, Lübeck

D-39120

Otto-von-Guericke-Universität University hospital Magdeburg, Magdeburg

D-48149

University, Hospital Münster, Münster

D-93053

Caritas Krankenhaus St.Josef Klinik für Urologie, Regensburg

D-72076

University Hospital Tuebingen, Tübingen

1066 CX

The Netherlands Cancer Institute - Oncology, Amsterdam

5604 DB

Maxima Medisch Centrum, Eindhoven

2300-RC

Leiden University Medical Center, Leiden

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

08041

Hospital de La Santa Creu i Sant Pau, Barcelona

EH4 2XU

Western General Hospital - Edinburgh Cancer Centre, Edinburgh

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

M20 4BX

The Christie NHS Foundation Trust, Manchester

HA6 2RN

Mount Vernon Hospital, Northwood

TR1 3LJ

Royal Cornwall Hospital (RCH) - Sunrise Centre, Truro

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Ipsen

INDUSTRY

NCT03945773 - Study of Cabozantinib as 2nd Line Treatment in Subjects With Locally Advanced or Metastatic Renal Cell Carcinoma (RCC) With a Clear-Cell Component Who Progressed After 1st Line Treatment With Checkpoint Inhibitors | Biotech Hunter | Biotech Hunter