A Phase I Study of Niraparib Administered Concurrently With Postoperative RT in Triple Negative Breast Cancer Patients

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

July 11, 2019

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2028

Conditions
Triple Negative Breast CancerResidual Disease
Interventions
DRUG

Niraparib

"Niraparib is a type of drug called a PARP inhibitor, which blocks DNA (the genetic material of cells) damage from being repaired or may prevent damage from occurring in the first place. In cancer treatment, inhibiting PARP may help kill cancer cells by not allowing the cancer cells to repair its DNA damage or prevent DNA damage from occurring."

RADIATION

Radiation Therapy

radiation therapy

Trial Locations (2)

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana Farber Cancer Institute/Brigham and Women's Hospital, Boston

All Listed Sponsors
collaborator

Tesaro, Inc.

INDUSTRY

lead

Massachusetts General Hospital

OTHER

NCT03945721 - A Phase I Study of Niraparib Administered Concurrently With Postoperative RT in Triple Negative Breast Cancer Patients | Biotech Hunter | Biotech Hunter