Safety, Tolerability and Pharmacodynamic Effect of Fazirsiran (TAK-999, ARO-AAT)

PHASE2CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

August 7, 2019

Primary Completion Date

November 8, 2021

Study Completion Date

September 18, 2023

Conditions
Alpha 1-Antitrypsin Deficiency
Interventions
DRUG

Fazisiran Injection

solution for subcutaneous (sc) injection

OTHER

Placebo

sterile normal saline (0.9% NaCl), calculated to match active comparator, for sc injection

Trial Locations (21)

10032

Columbia University Medical Center, New York

27100

Fondazione IRCCS Policlinico S. Matteo, Pavia

29425

Medical University of South Carolina (MUSC), Charleston

32610

University of Florida Hepatology Research at CTRB, Gainesville

35233

University of Alabama at Birmingham Medical Center, Birmingham

37232

Vanderbilt University Medical Center, Nashville

46202

Indiana University Health University Hospital, Indianapolis

52074

Universitatsklinikum Aachen, Anstalt des offentlich, Aachen

52242

University of Iowa Hospitals and Clinics, Iowa City

63104

SSM-Health Cardinal Glennon Children's Hospital, St Louis

77030

Baylor College of Medicine, Houston

84132

University of Utah Hospital, Salt Lake City

85054

Mayo Clinic Arizona, Phoenix

90095

UCLA David Geffen School of Medicine, Center for Health Sciences, Los Angeles

92037

University of California San Diego Altman Clinical and Translational Research Institute, La Jolla

94158

UCSF Medical Center Benioff Children's Hospital, San Francisco

94305

Stanford Health Care, Stanford

95817

University of California Davis Medical Center, Sacramento

2333 ZA

Leiden University Medical Center, Leiden

9004-514

Hospital Central Do Funchal (Hospital Nelio Mendoca), Funchal

08035

Hospital Universitari Vall d'Hebron, Barcelona

Sponsors
All Listed Sponsors
lead

Arrowhead Pharmaceuticals

INDUSTRY