DOSE Trial of Opioid Sparing Effect

PHASE1TerminatedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 18, 2019

Primary Completion Date

October 21, 2020

Study Completion Date

November 6, 2020

Conditions
DexmedetomidineMechanical Ventilation ComplicationCritically Ill
Interventions
DRUG

Fentanyl

Fentanyl standard of care

DRUG

Dexmedetomidine

Dexmedetomidine (0.5 mcg/kg + 0.2 mcg/kg/hr)

DRUG

Dexmedetomidine

Dexmedetomidine (0.5 mcg/kg + 0.5 mcg/kg/hr)

DRUG

Dexmedetomidine

Dexmedetomidine (0.5 mcg/kg + 0.7 mcg/kg/hr)

Trial Locations (19)

14203

University of Buffalo, Oishei Children's Hospital, Buffalo

14642

University of Rochester Medical Center, Golisano Children's Hospital, Rochester

19134

Drexel University, St. Christopher's Hospital for Children, Philadelphia

27157

Wake Forest Baptist Medical Center, Winston-Salem

27705

Duke University Medical Center, Durham

29425

Medical University of South Carolina Children's Hospital, Charleston

32608

University of Florida, Shands Children's Hospital, Gainesville

44106

Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland

44109

MetroHealth System, Case CTSA, Cleveland

46202

Indiana University Health, Riley Hospital for Children, Indianapolis

55454

University of Minnesota Masonic Children's Hospital, Minneapolis

63104

Saint Louis University, Cardinal Glennon Children's Hospital, St Louis

70808

Our Lady of the Lake Children's Hospital, Baton Rouge

72202

Arkansas Children's Hospital, Little Rock

78229

University of Texas - Health Science Center San Antonio, San Antonio

84113

Primary Children's Medical Center- University of Utah, Salt Lake City

87131

University of New Mexico Children's Hospital, Albuquerque

97239

Oregon Health and Science University, Doernbecher Children's Hospital, Portland

01655

UMass Memorial Medical Center, Children's Center, Worcester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

Johns Hopkins University

OTHER

collaborator

Intermountain Health Care, Inc.

OTHER

collaborator

Vanderbilt University Medical Center

OTHER

lead

Duke University

OTHER

NCT03938857 - DOSE Trial of Opioid Sparing Effect | Biotech Hunter | Biotech Hunter