Neoantigen Vaccine Plus Locally Administered Ipilimumab and Systemic Nivolumab in Advanced Melanoma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

November 11, 2020

Primary Completion Date

December 27, 2022

Study Completion Date

September 30, 2028

Conditions
Cutaneous Melanoma
Interventions
DRUG

Nivolumab (480 mg infusion)

Nivolumab is an antibody that prevent cancer cells from suppressing the immune response so that the body can attack and kill the cancer

BIOLOGICAL

NeoVax plus Montanide

Montanide® is an activator of immunity that enhances response to vaccination through slow release of the peptides from the injection site and its ability to create an inflammation and stimulate the recruitment of specific cells of your immune system. Montanide® will be mixed with the personalized neoantigen vaccine

DRUG

Ipilimumab

Ipilimumab is an antibody that prevent cancer cells from suppressing the immune response so that the body can attack and kill the cancer

Trial Locations (1)

02215

Dana Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Dana-Farber Cancer Institute

OTHER