Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

August 22, 2019

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2026

Conditions
Graft Versus Host Disease
Interventions
DRUG

Abatacept

All patients will receive 8 doses of abatacept (10 mg/kg intravenously on days -1, +5, +14, +28, +56, +84, +112, and +150) in addition to conventional GVHD prophylaxis.

Trial Locations (9)

10032

Columbia University Irving Medical Center, New York

14203

Oishei Children's Hospital, Buffalo

19803

Nemours/Alfred I. DuPont Hospital for Children, Wilmington

30322

Childrens Healthcare of Atlanta, Atlanta

35233

Children's of Alabama, Birmingham

39216

University of Mississippi Medical Center, Children's Center for Cancer and Blood Disorders, Jackson

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

02215

Dana-Farber Cancer Institute, Boston

07601

Hackensack Meridian Health, Hackensack

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Thrasher Research Fund

OTHER

collaborator

Sickle Cell Transplant Advocacy & Research Alliance (STAR)

UNKNOWN

collaborator

Aflac Cancer and Blood Disorders Center

UNKNOWN

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Emory University

OTHER