Cisplatin-based and Carboplatin-based Chemoradiation in Locoregionally Advanced Nasopharyngeal Carcinoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

482

Participants

Timeline

Start Date

January 31, 2018

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
CisplatinCarboplatinNPC
Interventions
DRUG

Docetaxel,Carboplatin

Patients receive docetaxel (75mg/m2 on day 1), carboplatin (AUC 4 on day 1) every three weeks for two cycles before the radiotherapy.

DRUG

Docetaxel,Cisplatin

Patients receive docetaxel (75mg/m2 on day 1), cisplatin (75mg/m2 on day 1) every three weeks for two cycles before the radiotherapy.

RADIATION

Carboplatin-based concurrent chemoradiotherapy

Patients receive radical radiotherapy and carboplatin (AUC 5) every three weeks for three cycles during radiotherapy.

RADIATION

Cisplatin-based concurrent chemoradiotherapy

Patients receive radical radiotherapy and cisplatin (100mg/m2) every three weeks for three cycles during radiotherapy.

Trial Locations (1)

510515

RECRUITING

Southern medical university, Guangzhou

All Listed Sponsors
lead

Nanfang Hospital, Southern Medical University

OTHER