Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

October 2, 2019

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2027

Conditions
Mesothelioma
Interventions
DRUG

Nivolumab Injection

Receive preoperative nivolumab, 240mg IV, on Day -42, -28 and Day -14 (+/- two days for each timepoint) prior to planned surgery on Day 0 (to allow for scheduling surgery may take place between Day -3 and Day +10).

DRUG

Ipilimumab Injection

Receive preoperative nivolumab, 3mg/kg IV, on Day -42, -28 and Day -14 (+/- two days for each timepoint) + ipilimumab 1mg/kg IV on Day -42 prior to planned surgery on Day 0 (to allow for scheduling surgery may take place between Day -3 and Day +10).

Trial Locations (3)

21201

Greenebaum Comprehensive Cancer Center University of Maryland School of Medicine, Baltimore

21287

Johns Hopkins University, Baltimore

77030

University of Texas M.D. Anderson Cancer Center, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

OTHER