PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

122

Participants

Timeline

Start Date

November 8, 2019

Primary Completion Date

October 31, 2023

Study Completion Date

December 31, 2028

Conditions
Breast Cancer
Interventions
DRUG

Leuprorelin acetate

In premenopausal women, 3.75mg of leuprorelin acetate is subcutaneously administered once every 4 weeks for 16 weeks. (if needed, maximum for 24 weeks)

DRUG

Letrozole

2.5 mg tablet is orally administered once a day, without regard to meals, for 16 weeks (if needed, maximum for 24 weeks)

GENETIC

MammaPrint

In this study, patients with MammaPrint test is performed, neoadjuvant chemotherapy is conducted to genomic High Risk patients, and neoadjuvant endocrine therapy is conducted to Low Risk patients.

Trial Locations (1)

Unknown

Seoul National University Hospital, Seoul

All Listed Sponsors
lead

Seoul National University Hospital

OTHER

NCT03900637 - PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate | Biotech Hunter | Biotech Hunter