Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery

PHASE4CompletedINTERVENTIONAL
Enrollment

782

Participants

Timeline

Start Date

May 30, 2019

Primary Completion Date

January 30, 2025

Study Completion Date

January 30, 2025

Conditions
Coronary Artery Bypass Graft SurgeryAtherosclerosisVein Occlusion
Interventions
DRUG

Evolocumab

REPATHA (evolocumab) is a human immunoglobulin G2 (IgG2) monoclonal antibody that has high affinity binding to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9); it will be administered via subcutaneous injection

OTHER

Placebo

Placebo cartridges will contain vehicle only; placebo will be administered via subcutaneous injection.

Trial Locations (22)

32216

Jacksonville Center for Clinical Research, Jacksonville

44106

University Hospital Cleveland Medical Center, Cleveland

55407

Minneapolis Heart Institute Foundation, Minneapolis

94121

San Francisco VA Medical Center, San Francisco

04102

Maine Medical Center, Portland

Unknown

Royal Adelaide Hospital, Adelaide

Flinders Medical Centre, Bedford Park

Monash University, Melbourne

Fiona Stanley Hospital, Murdoch

New Brunswick Heart Centre, Saint John's

Hamilton Health Sciences, Hamilton

One Heart Care, Mississauga

North York Diagnostic and Cardiology Centre, North York

Sunnybrook Health Sciences Center, North York

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec

Foothills Medical Centre, Calgary

Medical Centre Hungarian Defence Forces, Budapest

Semmelweis University Heart and Vascular Centre, Budapest

Zala Megyei Szent Rafael Korhaz, Zalaegerszeg

T6G 2R8

University of Alberta, Edmonton

K7L 2V7

Kingston Health Sciences Centre, Kingston

M5B 1W8

St. Michael's Hospital, Toronto

Sponsors
All Listed Sponsors
collaborator

Applied Health Research Centre

OTHER

lead

Unity Health Toronto

OTHER