A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome

PHASE2RecruitingINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

July 23, 2019

Primary Completion Date

October 31, 2025

Study Completion Date

May 31, 2027

Conditions
Richter Syndrome
Interventions
DRUG

Acalabrutinib

100mg capsule, PO, BD

DRUG

Cyclophosphamide

750mg/m\^2, IV bolus

DRUG

Doxorubicin

50mg/m\^2, IV bolus

DRUG

Vincristine

1.4mg/m\^2, IV infusion

DRUG

Prednisolone

40mg/m\^2, PO, OD

DRUG

Rituximab

375mg/m\^2, IV infusion

Trial Locations (16)

Unknown

RECRUITING

Belfast City Hospital, Belfast

RECRUITING

Royal Bournemouth Hospital, Bournemouth

RECRUITING

University Hospital of Wales, Cardiff

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

RECRUITING

St James's University Hospital, Leeds

RECRUITING

Leicester Royal Infirmary, Leicester

RECRUITING

King's College Hospital, London

RECRUITING

St Bartholomew's Hospital, London

RECRUITING

University College London Hospital, London

RECRUITING

Christie Hospital, Manchester

RECRUITING

Norfolk and Norwich University Hospital, Norwich

RECRUITING

Nottingham City Hospital, Nottingham

RECRUITING

Churchill Hospital, Oxford

RECRUITING

Derriford Hospital, Plymouth

RECRUITING

Royal Hallamshire Hospital, Sheffield

RECRUITING

Southampton General Hospital, Southampton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bloodwise

OTHER

collaborator

Acerta Pharma, LLC

OTHER

lead

University of Birmingham

OTHER

NCT03899337 - A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome | Biotech Hunter | Biotech Hunter