An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)

PHASE2RecruitingINTERVENTIONAL
Enrollment

267

Participants

Timeline

Start Date

July 18, 2019

Primary Completion Date

September 9, 2029

Study Completion Date

September 9, 2029

Conditions
Melanoma
Interventions
DRUG

mRNA-4157

Individualized Neoantigen Therapy

BIOLOGICAL

Pembrolizumab

Intravenous infusion

Trial Locations (22)

2060

ACTIVE_NOT_RECRUITING

Melanoma Institute Australia, North Sydney

2145

ACTIVE_NOT_RECRUITING

Westmead Hospital, Westmead

4102

ACTIVE_NOT_RECRUITING

Princess Alexandra Hospital, Woolloongabba

6008

RECRUITING

St John of God Hospital Subiaco, Subiaco

6150

ACTIVE_NOT_RECRUITING

Affinity Clinical Research, Murdoch

10016

RECRUITING

NYU Langone Medical Center, New York

20007

RECRUITING

Lombardi Cancer Center, Washington D.C.

30342

RECRUITING

Northside Hospital, Atlanta

32806

RECRUITING

Orlando Health UF Health Cancer Center, Orlando

37203

RECRUITING

Sarah Cannon Cancer Center, Nashville

60637

RECRUITING

UPMC Hillman Cancer Center, Chicago

63110

RECRUITING

Washington University School of Medicine, St Louis

75246

RECRUITING

Texas Oncology PA, Dallas

80045

RECRUITING

University of Colorado Cancer Center, Aurora

85719

RECRUITING

University of Arizona, Tucson

90404

RECRUITING

Angeles Clinic and Research Institute, Santa Monica

94115

RECRUITING

California Pacific Medical Center Research Institute -CPMCRI, San Francisco

97213

RECRUITING

Providence Cancer Institute, Portland

06520

RECRUITING

Smilow Cancer Center at Yale New Haven Hospital, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

02115

RECRUITING

Dana Farber Cancer Institute, Boston

07601

RECRUITING

Hackensack University Medical Center, Hackensack

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

ModernaTX, Inc.

INDUSTRY

NCT03897881 - An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942) | Biotech Hunter | Biotech Hunter