A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

May 21, 2019

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
CancerAdvanced Solid TumorsTriple-Negative Breast Cancer (TNBC)Non-small-cell-lung-cancer (NSCLC)Metastatic Solid Tumors
Interventions
DRUG

ABBV-927

Intravenous (IV) Infusion

DRUG

ABBV-368

Intravenous (IV) Infusion

DRUG

ABBV-181

Intravenous (IV) Infusion

DRUG

Carboplatin

Intravenous (IV) Infusion

DRUG

Nab-paclitaxel

Intravenous (IV) Infusion

Trial Locations (26)

100

National Taiwan University Hospital /ID# 210993, Taipei City

4101

Duplicate_Icon Cancer Centre /ID# 224084, South Brisbane

15232

UPMC Hillman Cancer Ctr /ID# 222747, Pittsburgh

22031

Virginia Cancer Specialists - Fairfax /ID# 210671, Fairfax

28040

Hospital Universitario Fundacion Jimenez Diaz /ID# 212806, Madrid

28050

Hospital Universitario HM Sanchinarro /ID# 212805, Madrid

28078

Carolina BioOncology Institute /ID# 210664, Huntersville

29010

Hospital Universitario Virgen de la Victoria /ID# 221671, Málaga

40447

China Medical University Hospital /ID# 221090, Taichung

44805

Institut de Cancérologie de l'Ouest René Gauducheau /ID# 212880, Saint-Herblain

46804

Fort Wayne Medical Oncology and Hematology, Inc /ID# 226072, Fort Wayne

63011

Centre Jean Perrin /ID# 217911, Clermont-Ferrand

63110

Washington University-School of Medicine /ID# 221399, St Louis

69373

Centre Leon Berard /ID# 217910, Lyon

72762

Highlands Oncology Group, PA /ID# 218863, Springdale

75018

AP-HP - Hopital Bichat - Claude-Bernard /ID# 212869, Paris

75230

Mary Crowley Cancer Research /ID# 210716, Dallas

75248

Institut Curie /ID# 223475, Paris

78229

NEXT Oncology /ID# 210717, San Antonio

95403

St Jude Hospital dba St Joseph /ID# 211130, Santa Rosa

5265601

The Chaim Sheba Medical Center /ID# 211699, Ramat Gan

06510

Yale University School of Medicine /ID# 210678, New Haven

33612-9416

Moffitt Cancer Center /ID# 215037, Tampa

27710-3000

Duke Cancer Center /ID# 217641, Durham

37203-1632

Tennessee Oncology-Nashville Centennial /ID# 221400, Nashville

08035

Hospital Universitario Vall d'Hebron /ID# 212804, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY