70
Participants
Start Date
July 30, 2019
Primary Completion Date
December 31, 2024
Study Completion Date
December 31, 2024
IV lidocaine
an amide-type, short-acting local anesthetic and delivered as an aqueous solution for intravenous administration. It has a half-life of 1.5-2 hours. A traditional method of administration is via epidural delivery. Epidural lidocaine is effective and this effect is due, in part, to systemic absorption. Systemic (intravenous) administration of lidocaine is a Food and Drug Administration approved method of delivery. Low plasma levels are needed for effective use, 0.5µg/mL to 5.0µg/mL. Given this low concentration required and the short half-life, continuous infusion of lidocaine is thought to be generally safe with low risk of complication.
Placebos
Saline
Barnes Jewish Hospital and St. Louis Children Hospital / Washington University in St. Louis School of Medicine, St Louis
Washington University School of Medicine
OTHER