A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

August 19, 2019

Primary Completion Date

August 1, 2020

Study Completion Date

March 6, 2026

Conditions
Stage III Uterine Corpus Leiomyosarcoma AJCC v8Stage IV Uterine Corpus Leiomyosarcoma AJCC v8Uterine Corpus Leiomyosarcoma
Interventions
PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Core Biopsy

Undergo tumor biopsy

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Olaparib

Given PO

DRUG

Temozolomide

Given PO

Trial Locations (15)

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

23298

VCU Massey Comprehensive Cancer Center, Richmond

32610

University of Florida Health Science Center - Gainesville, Gainesville

43210

Ohio State University Comprehensive Cancer Center, Columbus

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48334

Weisberg Cancer Treatment Center, Farmington Hills

55905

Mayo Clinic in Rochester, Rochester

63110

Washington University School of Medicine, St Louis

80045

UCHealth University of Colorado Hospital, Aurora

85054

Mayo Clinic Hospital in Arizona, Phoenix

94304

Stanford Cancer Institute Palo Alto, Palo Alto

32224-9980

Mayo Clinic in Florida, Jacksonville

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH