Benefit of a Flash Dose of Corticosteroids in Digestive Surgical Oncology: a Randomized, Double Blind, Placebo-controlled Trial

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,200

Participants

Timeline

Start Date

July 2, 2019

Primary Completion Date

February 29, 2024

Study Completion Date

September 30, 2027

Conditions
Elective Surgery for Any Digestive Cancer
Interventions
DRUG

Injection of methylprednisolone

Patients will receive 20mg/kg IV of methylprednisolone at the time of anaesthetic induction. Methylprednisolone will be infused in a ready-to-use 50 mL bag of sodium chloride 0.9% during 30 minutes at anaesthesic induction.

DRUG

Injection of sodium chloride

patients in the placebo group will receive 50 mL of sodium chloride 0.9% in a ready-to-use bag during 30 minutes at anaesthesic induction.

BIOLOGICAL

Blood samples

electrolyte panel and glycemia performed within the first 24 hours after surgery.

Trial Locations (1)

21079

Chu de Dijon, Dijon

All Listed Sponsors
lead

Centre Hospitalier Universitaire Dijon

OTHER