Neoadjuvant IBI308, Bevacizumab, Plus Pemetrexed and Carboplatin Followed by Surgery in Unresectable Stage III NSCLC

PHASE2RecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

March 1, 2019

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2026

Conditions
Lung Cancer Stage III
Interventions
DRUG

IBI308

IBI308 was given 200 mg iv infusion on day 1 of each 21-day cycle for 4 cycles.

DRUG

Bevacizumab

Bevacizumab was administered at a dose of 15 mg/kg on day 1 of each 21-day cycle for 4 cycles.

DRUG

Pemetrexed

Pemetrexed was given 500 mg/m\^2 i.v. injection on day 1 of each 21-day cycle for 4 cycles.

DRUG

Carboplatin

Carboplatin was given dosed to an area under the serum concentration-time curve (AUC) of 5 i.v. on day 1 of each 21-day cycle for 4 cycles.

PROCEDURE

Thoracic surgery

Surgery will be performed at least 21 days after the last dose of neoadjuvant therapy.

Trial Locations (1)

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER