Pre-operAtive Non-Anthracycline Chemotherapy, Durvalumab +/- RAdiation Therapy in Triple Negative Breast Cancer

PHASE2WithdrawnINTERVENTIONAL

Timeline

Start Date

July 31, 2022

Primary Completion Date

July 31, 2022

Study Completion Date

July 31, 2027

Conditions

Breast CancerTriple Negative Breast Cancer

Interventions

DRUG

Durvalumab

IV administration of 5 treatments;every 2 weeks for 2 treatments and then every 4 weeks for 3 treatments

RADIATION

Radiation Therapy

The second dose of durvalumab will be given in conjunction with an RT boost, consisting of 8 Gy in 3 fractions for a total of 24 Gy.

DRUG

Carboplatin

IV administration weekly for 12 weeks

DRUG

Paclitaxel

IV administration every week for 12 weeks

Trial Locations (1)

Cedars Sinai Medical Center, Los Angeles