Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 2)

PHASE2CompletedINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

March 7, 2019

Primary Completion Date

August 6, 2019

Study Completion Date

August 6, 2019

Conditions
Raynaud Phenomenon Secondary to Systemic Sclerosis
Interventions
DRUG

Placebo IV infusion

Study drug will be initiated at a starting dose of 0.5 ng/kg/min up to 2.0 ng/kg/min. Subjects will receive study drug for 5 consecutive days as an IV infusion over 6 hours each day via a peripheral line.

DRUG

Iloprost Injection, for intravenous use

Study drug will be initiated at a starting dose of 0.5 ng/kg/min up to 2.0 ng/kg/min. Subjects will receive study drug for 5 consecutive days as an IV infusion over 6 hours each day via a peripheral line.

Trial Locations (16)

10021

Hospital for Special Surgery, New York

10032

Columbia University Medical Center, New York

15261

University of Pittsburgh Medical Center, Pittsburgh

20007

Georgetown University Medical Center - Department of Rheumatology, Washington D.C.

21224

Johns Hopkins University School of Medicine, Baltimore

43614

The University of Toledo Medical Center (UTMC) - Ruppert Health Center, Toledo

44195

Cleveland Clinic, Cleveland

77030

University of Texas Houston - Division of Rheumatology and Clinical Immunogenetics, Houston

85032

Arizona Arthritis & Rheumatology Research, PLLC, Phoenix

90045

Pacific Arthritis Care Center of Los Angeles, Los Angeles

94143

University of California San Francisco, San Francisco

94305

Stanford University Medical Center, Palo Alto

98101

Virginia Mason Medical Center, Seattle

99204

Arthritis Northwest Rheumatology PLLC, Spokane

48109-5422

University of Michigan, Ann Arbor

08903

Robert Wood Johnson Medical School, New Brunswick

Sponsors
All Listed Sponsors
lead

Civi Biopharma, Inc.

INDUSTRY