Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

January 2, 2018

Primary Completion Date

July 11, 2022

Study Completion Date

May 29, 2023

Conditions
Advanced Solid TumorsMetastatic Melanoma
Interventions
DRUG

losartan

taken orally

DRUG

dextromethorphan

taken orally

DRUG

caffeine

taken orally

DRUG

omeprazole

taken orally

DRUG

midazolam

taken orally

DRUG

rosuvastatin

taken orally

DRUG

bupropion immediate release (IR)

taken orally

DRUG

encorafenib

taken orally

DRUG

binimetinib

taken orally

DRUG

modafinil

taken orally

Trial Locations (29)

2650

Universitair Ziekenhuis Antwerpen, Edegem

25198

Hospital Universitari Arnau de Vilanova, Lleida

28007

Hospital Beata Maria Ana, Madrid

Hospital General Universitario Gregorio Marañon, Madrid

28010

Clinica Rementeria, Madrid

28033

MD Anderson Cancer Center Madrid, Madrid

28050

Hospital Universitario HM Sanchinarro - CIOCC, Madrid

30120

Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar

37920

University of TN Medical Center, Knoxville

41009

CERCO, Seville

Hospital Universitario Virgen Macarena, Seville

44718

Gabrail Cancer Center Research, Canton

55101

Regions Cancer Care Center, Saint Paul

55130

HealthPartners Specialty Center-Eye Care, Saint Paul

55369

Park Nicollet Eye Clinic, Maple Grove

60612

University of Illinois at Chicago, Chicago

75230

Mary Crowley Cancer Research - Medical City Hospital, Dallas

80045

University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora

84119

Utah Cancer Specialists, West Valley City

92868-3201

UC Irvine Health, Orange

55343-8087

Hopkins Eye Clinic, Hopkins

T6G 1Z2

Cross Cancer Institute, Edmonton

M5G 2M9

Princess Margaret Cancer Centre, Toronto

H3T 1E2

Sir Mortimer B Davis Jewish General Hospital, Montreal

Jewish General Hospital, Montrea

H4A 3J1

McGill University Health Center, Montreal

1066 CX

Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam

3000 CA

Erasmus Medical Center, Rotterdam

08003

Hospital del Mar, Barcelona

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Pierre Fabre Laboratories

INDUSTRY

lead

Pfizer

INDUSTRY